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Statins

-statin
How it works

Block HMG-CoA reductase, the liver's cholesterol factory → LDL falls, plaque stabilizes.

You'll see
atorvastatinrosuvastatinsimvastatin
Used for
High cholesterolPost-MI / stroke secondary preventionDiabetes with cardiovascular risk
Side effects
Muscle aches → rarely rhabdomyolysisLiver enzyme elevationGI upset
Monitor
  • New muscle pain + dark urine = check CK, hold and call — that's the rhabdo picture
  • Baseline and PRN LFTs
🎓 Patient teaching

Report unexplained muscle pain, especially with brown urine. Often dosed in the evening (cholesterol synthesis peaks overnight). Avoid grapefruit with simvastatin/atorvastatin.

Source: Lehne's Pharmacology for Nursing Care, 11th ed.Reference only — verify against your facility's policy.

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